The Neapolitan Mastiff is a strapping, imposing and often powerful dog. It is heavy-boned, and its body is longer rather than it is tall. It weighs 120 to 200 pounds and stands 60 to 78 centimetres at the withers. Its large head is wrinkled with folds extending from the outside edges of the eyelids to the dewlap, and from below the lower lids to the external edges of the lips. The muzzle is moderately long against the head and should just be as wide. It has a large nose matching the colour of its coat, while its ears form small triangles and are either natural or cropped. The tail is set low and often docked.
The Neapolitan Mastiff wears a short and dense coat that is smooth to touch. Its coat comes in shades of blue, black, mahogany, reverse brindle, or tawny. Despite its large form, is low maintenance when it comes to grooming, thanks to its short and glossy coat. However, the folds and wrinkles around the face must be checked, cleaned and dried regularly to avoid bacteria setting in and developing infections.
Like most dogs, Neapolitans shed throughout the year and more during spring and autumn, which may require frequent grooming. It's also important to pay close attention to other basic grooming needs. Check the dog's ears regularly and clean them when necessary to avoid ear infections. Brush its teeth often to keep gum disease and bad breath at bay. Also, make sure to trim its nails to prevent overgrowth, splitting and cracking, often painful for the dog.